In this study, intending to control the corrosion of magnesium and its clinical application, a double-layer coating of Hydroxyapatite- Poly lactic-co-glycolic acid was applied on Mg by means of the electrodeposition and the dip method, respectively. X-ray diffraction (XRD) and scanning electron microscopy (SEM) are used to characterize the phase and morphology of the coatings. The results show a homogeneous coating with a thickness of 20-30 µm. Potentiodynamic polarization of the samples revealed that the double-layer coating exhibited a significant increase in corrosion potential, ranging from -1.82 to -1.4 V, and a decrease in corrosion current, ranging from 2.3 to 0.37 µA/cm2. Moreover, the MTT assay of the samples revealed that the amount of cell proliferation in the vicinity of the 48-hour extract of magnesium samples with double-layer coating had increased, indicating a decrease in the amount of ions released from the surface of magnesium by applying this coating.

Hypothesis: In order to reduce the environmental pollution, it is an inevitable approach to replace petroleum polymers with biodegradable materials. Poly(lactic acid) (PLA) is one of the suitable alternatives for synthetic polymers, due to its biodegradability and biocompatibility as well as high tensile strength, but the application of PLA faces limitations due to its brittleness.Methods: In this research, blends of PLA containing 25% (by wt) poly(butylene adipate-co-terephthalate) (PBAT), a biodegradable and flexible polymer, were prepared. Nanocomposites containing 1 and 3 phr nanoclay (Cloisite 20A) were prepared at the same time. The compatibilizing effect of chain extender (CE) (ADR 4368) (0.5 phr) for this system was investigated. The rheological, morphological, mechanical and thermal properties of all samples have been studied. Findings: Rheology results show a significant increase in the storage modulus and complex viscosity of samples containing both nanoclay and chain extender. SEM images illustrate droplet-matrix morphology of all samples. It is shown that the size of PBAT dispersed phase in nanocomposites is decreased, especially in the sample containing 3 phr nanoclay and 0.5 phr chain extender (2.54 to 1.15 mm). The results of mechanical tests show that all nanocomposites, specially samples containing both nanoclay and chain extender have made a significant improvement in all mechanical properties, in comparison to a neat PLA (about 13.6 times in elongation-at-break and more than twice in impact strength for nanocomposite containing 3 phr nanoclay and 0.5 phr chain extender). These findings confirm the results of rheology and morphology and reveal a synergistic effect of using nanoclay and chain extender for the compatibilization of the system. The XRD analysis reveals an increase in the distance of nanoclay plates, which is due to diffusion of polymer chains into its layers. Finally, the DSC analysis shows that the crystallinity of the samples increases in the presence of nanoclay particles.